coeruleus is one of the brainstem nuclei that maintains
close communications with the amygdala. This small nucleus
contains almost half of all the brain neurons that use
norepinephrine as a neurotransmitter. The locus coeruleus
also projects its axons to those parts of the brain that
may be associated with panic disorders (the amygdala, hippocampus,
septum, cortex, brainstem, reticular formation, etc).
Stimulating an animal's locus coeruleus, like stimulating
its amygdala, produces anxiety behaviours. As therefore
follows logically, substances with tranquilizing effects,
such as benzodiazepines, alcohol,
make the locus coeruleus less active.