Experiment Module: Experimentally Induced Long-Term
Pairing a presynaptic activity with a postsynaptic activity
results in long-term potentiation (LTP). Applying a single stimulus to a Schaffer
collateral pathway of the presynaptic neuron causes an excitatory postsynaptic
potential (EPSP) in a pyramidal cell in the CA1 region, but does not cause any
strengthening of the synaptic connection.
if, at the same time as the Schaffer collateral pathway is stimulated in the presynaptic
neuron, a current is injected via the recording electrode into the postsynaptic
CA1 neuron to depolarize its membrane potential briefly; then the EPSPs in this
neuron are strengthened for a prolonged period.
Gustafsson et al., 1987)